Kompetenzzentrum Algenbiotechnologie

Makay, K.; Griehl, C.; Grewe, C.: Development of a high-performance thin-layer chromatography-based method for targeted glycerolipidome profiling of microalgae. Anal Bioanal Chem (2024). DOI:10.1007/s00216-023-05101-y.

Sandgruber, F.; Gielsdorf, A.; Schenz, B.; Müller, S.M.; Schwerdtle, T.; Lorkowski, S.; Griehl, C.; Dawczynski, C.: Variability in Macro- and Micronutrients of 15 Rarely Researched Microalgae. Mar. Drugs, 21, 355 (2023). DOI:10.3390/md21060355.

Griehl, C.; Schmid, A.; Wilhelm, C.: Meilensteine in der Algenbiotechnologie. BIOspektrum, 29(3), 306-309 (2023). DOI:10.1007/s12268-023-1942-7.

Brückner, K.; Griehl, C.: Permeabilization of the cell wall of Chlorella sorokiniana by the chitosan-degrading protease papain. Algal Research, 71, 103066 (2023). DOI:10.1016/ j.algal.2023.103066.

Sandgruber, F.; Höger, A.-L.; Kunze, J.; Schenz, B.; Griehl, C.; Kiehntopf, M.; Kipp, K.; Kühn, J.; Stangl, G.I.; Lorkowski, S.; et al.: Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients, 15, 1645 (2023). DOI:10.3390/nu15071645.

Kryvenda, A.; Tischner, R.; Steudel, B.; Griehl, C.; Armon, R.; Friedl, T.: Testing for terrestrial and freshwater microalgae productivity under elevated CO₂ conditions and nutrient limitation. BMC Plant Biol 23, 27 (2023). DOI:10.1186/s12870-023-04042-z.

Kühn, J.; Brandsch, C.; Kiourtzidis, M.; Nier, A.; Bieler, S.; Matthäus, B.; Griehl, C.; Stangl, G.I.: Microalgae-derived sterols do not reduce the bioavailability of oral vitamin D3 in mice. Int J Vitam Nutr Res (2022). DOI:10.1024/0300-9831/a000766.

Höger, A. L.; Jehmlich, N.; Kipping, L.; Griehl, C.; Noll, M.: Associated bacterial microbiome responds opportunistic once algal host Scenedesmus vacuolatus is attacked by endoparasite Amoeboaphelidium protococcarum. Scientific Reports, 12(1), 13187 (2022). DOI:10.1038/s41598-022-17114-1.

Kettner, A.; Noll, M.; Griehl, C.: Leptolyngbya sp. NIVA-CYA 255, a Promising Candidate for Poly(3-hydroxybutyrate) Production under Mixotrophic Deficiency Conditions. Biomolecules, 12, 504 (2022). DOI: 10.3390/biom12040504.

Kleinert, C.; Griehl, C.: In situ extraction (milking) of two promising Botryococcus braunii strains Showa and Bot22 under optimized extraction time. J Appl Phycol 34, 269 (2022). DOI:10.1007/s10811-021-02633-7.

Kettner, A.; Noll,M.; Griehl, C.: In situ quantification of poly(3-hydroxybutyrate) and biomass in Cupriavidus necator by a fluorescence spectroscopic assay. Appl Microbiol Biotechnol 106, 635–645 (2022). DOI: 10.1007/s00253-021-11670-8.

Klose, J.; Griehl, C.; Roßner, S.; Schilling, S.: Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules, 12(5), 694 (2022). DOI:10.3390/biom12050694.

Makay, K.; Griehl, C.; Grewe, C.: Downstream Process Development for Multiproduct Recovery of High‐Value Lead Compounds from Marine Microalgae. Chem. Ing. Tech. 94(9), 1254 (2022). DOI: 10.1002/cite.202255193.

Höger, A. L.; Griehl, C.; Noll, M.: Infection with intracellular parasite Amoeboaphelidium protococcarum induces shifts in associated bacterial communities in microalgae cultures. J Appl Phycol 33, 2863–2873 (2021). DOI:10.1007/s10811-021-02542-9.

Sandgruber, F.; Gielsdorf, A.; Baur, A.C.; Schenz, B.; Müller, S.M.; Schwerdtle, T.; Stangl, G.I.; Griehl, C.; Lorkowski, S.; Dawczynski, C.: Variability in Macro- and Micronutrients of 15 Commercially Available Microalgae Powders. Mar. Drugs, 19, 310 (2021). DOI:10.3390/md19060310.

Duvigneau, S.; Kettner, A.; Carius, L.; Griehl, C.; Findeisen, R.; Kienle A.: Fast, inexpensive, and reliable HPLC method to determine monomer fractions in poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Appl Microbiol Biotechnol 105, 4743–4749 (2021). DOI: 10.1007/s00253-021-11265-3

Griehl, C.; Kettner, A.; Noll, M., Bieler S.: Fluorimetrische Bestimmung von intrazellulären Polyhydroxyalkanoaten. Biospektrum 27, 152–155 (2021). DOI: 10.1007/s12268-021-1558-8

Kettner, A.; Griehl, C.: The Use of LipidGreen2 for Visualization and Quantification of Intracellular Poly(3-hydroxybutyrate) in Cupriavidus necator. Biochem. Biophys. Rep. 24, 100819 (2020), DOI: 10.1016/ j.bbrep.2020.100819

Grewe, C.; Büschelberger, F.; Brückner, K.; Griehl, C.: Verfahrensentwicklung zur Extraktion von lipophilen und hydrophilen Extrakten aus Mikroalgen‐Biomasse als Rohstoffe für Cosmeceuticals. Chem. Ing. Tech. 92, 9, 1209 (2020), DOI: 10.1002/cite.202055125.

Kleinert, C.; Griehl, C.: Milking (In‐Situ‐Extraktion) von Kohlenwasserstoffen während der Kultivierung ausgewählter Mikroalgen. Chem. Ing. Tech. 92, 9, 1217-1218 (2020), DOI: 10.1002/cite.202055101.

Hielscher-Michael, S.; Griehl, C.; Buchholz, M.; Demuth, H.-U.; Arnold, N.; Wessjohann, L.A.: Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids are Potent Glutaminyl Cyclase Inhibitors. Mar. Drugs 14, 203 (2016). DOI:10.3390/md14110203.

Griehl, C.; Kleinert, C.; Griehl, C.; Bieler, S.: Design of a continuous milking bioreactor for non-destructive hydrocarbon extraction from Botryococcus braunii. J. Appl. Phycol. 27:1833-1843 (2015). DOI:10.1007/s10811-014-0472-6.

Krause-Hielscher, S.; Demuth, H.-U.; Wessjohann, L.; Arnold, N.; Griehl, C.: Microalgae as source for potential anti-Alzheimer´s Disease directed compounds - Screening for Glutaminyl Cyclase (QC) inhibiting metabolites. Internat. J. of Pharmacy and Biological Science 5, 4, 164-170 (2015). ISSN: 2230-7605 (Online)

Matthes, S.; Matschke, M.; Cotta, F.; Grossmann, J.; Griehl, C.: Reliable production of microalgae biomass using a novel microalgae platform. J. Appl. Phycol. 27:1755-1762 (2015). DOI: 10.1007/s10811-014-0502-4

Griehl, C.; Bieler, S.: Algen – Nachwachsende Rohstoffe für Gesundheit, Schönheit und Energie. Nachrichten aus der Chemie 59, 10, 942-947 (2011). DOI:10.1002/nadc.201190063.

Grewe, C.; Griehl, C.: Time- and media-dependent secondary carotenoid accumulation in Haematococcus pluvialis. Biotechnology Journal, 3, 1232-1244 (2008). DOI:10.1002/biot.200800067.

C. Griehl, C. Hecht, S. Streuber, Y. Ganß, H. Kremp: Bestimmung von Phenylessigsäure zur Früherkennung von Prozessstörungen in Biogasanlagen: Chem. Ing. Tech. 82, 12, 2223-2229 (2010), DOI: 10.1002/cite.200900064

C. Griehl, C. Grewe, A. Pfeiffer, L. Urban, W. Loettel: Lutein formation in green microalgae depending on light quality and carbon dioxide concentration. Chem. Ing. Tech. 81, 8, 1229-1230 (2009), DOI: 10.1002/cite.200950347

C. Griehl, Y. Ganß, C. Hecht, S. Streuber: Früherkennung von Prozessstörungen in Biogasanlagen. Chem. Ing. Tech. 81, 8, 1228 (2009), DOI: 10.1002/cite.200950343

C. Griehl, D. Müller, C. Künstler: Mikroalgen als CO₂-Verwerter und Wertstoffquelle. Chem. Ing. Tech. 81, 8, 1220 (2009), DOI: 10.1002/cite.200950367

C. Hecht, C. Griehl: Investigations on the accumulation of aromatic compounds during biogas production from kitchen wastes. Bioresour. Technol. 100, 654–658 (2009), DOI: 10.1016/j.biortech.2008.07.034

C. Grewe, C. Griehl: Time- and media-dependant secondary carotenoid accumulation in Haematococcus pluvialis. Biotechnol. J. 3, 9-10, 1232-1244 (2008), DOI: 10.1002/biot.200800067

C. Hecht, S. Bieler, H. Kremp, C. Griehl: Untersuchungen zur Prozessstabilität bei der Vergärung von Speiseabfällen. Chem. Ing. Tech. 79, 9, 1349-1350 (2007), DOI: 10.1002/cite.200750245

C. Grewe, S. Menge, C. Griehl: Enantioselective separation of all-E-astaxanthin and its determination in microbial sources. J. Chromatogr. A, 1166, 97-100 (2007), DOI: 10.1016/j.chroma.2007.08.002

C. Hecht, C. Griehl: Untersuchungen zu Inhibierungen bei der Vergärung proteinreicher Reststoffe. Beiträge zu Abfallwirtschaft/Altlasten 46, 109-121 (2006)

C. Griehl, S. Bieler, C. Hecht: Energiegewinnung aus Speiseresten. Chem. Ing. Tech. 78, 9, 1404 (2006), DOI: 10.1002/cite.200650285

C. Hecht, S. Bieler, C. Griehl: Liquid chromatographic mass spectrometric analyses of anaerobe protein degradation products. J. Chromatogr. A, 1088 (1-2), 23, 121-125 (2005), DOI: 10.1016/j.chroma.2005.05.055

F. Hoffmann, L. Jäger, C. Griehl: Synthesis and chemical constitution of diphenoxyphosphoryl derivatives and phosphonium salts as coupling reagents for peptide segment. Phosphorus, Sulfur and Silicon 178, 299-309 (2003), DOI: 10.1080/10426500307942

C. Griehl, S. Bieler, A. Platz, U. Junghannß, R. Vollmer: Untersuchungen zur Vergärbarkeit proteinreicher Substrate. Chem. Ing. Tech. 75, 3, 309-312 (2003), DOI: 10.1002/cite.200390064

A. Kolbe, C. Griehl, S. Bieler: Molecular interactions in conjugates of dicarboxylic acids and amino acids - An Infrared and Raman study. Journal of Molecular Structure, 661-662C, 239-246 (2003), DOI: 10.1016/S0022-2860(03)00446-0

C. Griehl, U. Junghannß, S. Bieler, R. Vollmer: Mikrobiologische und analytische Untersuchungen zur Vergärbarkeit proteinreicher Substrate. Chem. Ing. Tech. 5, 695-696 (2002)

C. Griehl, R. Andrecki, S. Bieler, I. Thondorf: New strategies for the asymmetric synthesis of peptides via conjugate addition of N-nucleophiles. Peptides 2002, Ettore Benedetti and Carlo Pedone (Eds.), Edizioni Ziino, Napoli, Italy, 120-121 (2002)

C. Griehl, S. Bieler, A. Kolbe: Synthesis and spectroscopical studies of new unsaturated amino acid derivatives as precursors for stereoselective synthesis. Peptides 2000, J. Martinez, J.-A. Fehrentz (Eds), Editions EDK, Paris, 221-222 (2001)

S. Bieler, C. Griehl: Stereoselective Synthesis of Aspartyl Peptides via C-N-Bond-Formation. Peptides 2000, J. Martinez, J.-A. Fehrentz (Eds), Editions EDK, Paris, 195-196 (2001)

M. Plass, C. Griehl, A. Kolbe: Solvent effect on the conformational behaviour of amino acid and oligopeptide derivatives. Journal of Molecular Structure 570, 203-214 (2001), DOI: 10.1016/S0022-2860(01)00517-8

F. Hoffmann, A. Kolbe, C. Griehl: Solid state and solution structures of a commonly used peptide coupling additive. J. Molecular Structure 476, 289-294 (1999), DOI: 10.1016/S0022-2860(98)00582-1

F. Hoffmann, A. Kolbe, C. Griehl: Structural influence of peptide coupling additives on reactivity and stereomutation in peptide synthesis. Peptides 1998, S. Bajusz, F. Hudecz (Eds), Akademiai Kiado 1999, 214-215

C. Griehl, F. Hoffmann, W. Brandt, M. Plass: Preferred application of coupling reagents during segment condensation. Peptides 1998, S. Bajusz, F. Hudecz (Eds), Akademiai Kiado 1999, 212-213

F. Hoffmann, C. Griehl: Crystal structure of 1-hydroxy-1,2,3-benzotriazolium diphenyl phosphate reveals strong NHO and OHO hydrogen bonds. J. Molecular Structure 440, 113-119 (1998), DOI: 10.1016/S0022-2860(97)00230-5

C. Griehl, H. Ludwig, W. Weißflog: Peptide Synthesis in Liquide-Crystalline Solvents. Peptides: Chemistry, Structure and Biology, P. T. P. Kaumaya, R. S. Hodges (Eds.), Mayflower Scientific Ltd., England 1996

C. Griehl, H.-D. Schädler, L. Jäger, M. Plass and A. Kolbe: Carboxyactivation of peptide fragments with new coupling reagents. Peptides 1996, R. Ramage, R. Epton (Eds.), MPG Books LTd 1998, 437-438

C. Griehl, S. Merkel, A. Kolbe: Quantitative description of epimerization pathways using the carbodiimide method in the synthesis of peptides. J. Chem. Soc. Perkin Trans 2, 2525-2529 (1996), DOI: 10.1039/p29960002525

C. Griehl, S. Merkel: Synthesis and separation of protected tripeptide diastereomers by RP-HPLC. Int. J. Peptide Protein Research 45, 217-224 (1995), DOI: 10.1111/j.1399-3011.1995.tb01483.x

M. Plass, C. Griehl und A. Kolbe: The Association Behaviour of Selected Amino Acids and Oligopeptide Derivatives with Fluorinated Alcohols. J. Chem. Soc. Perkin Trans 2, 853-856 (1995), DOI: 10.1039/p29950000853

C. Griehl, H. Jeschkeit: Einfacher gravimetrischer Racemisierungstest. J. prakt. Chem. 336, 77-78 (1994), DOI: 10.1002/prac.19943360117

C. Griehl, J. Weigt, H. Jeschkeit: Use of Tryptophan Peptides for a HPLC Racemization Test with Fluorescence Detection. J. High Resolution Chromatography 17, 700-704 (1994), DOI: 10.1002/jhrc.1240171004

C. Griehl, H. Jeschkeit: a-Aspartyl Peptides by Addition of Amines to N-Maleylamino Acid Derivatives. Chemistry of Peptides and Proteins, Vol. 5/6, DWI Reports 1993, 99-103

C. Griehl, J. Weigt, H. Jeschkeit, Z. Palacz: HPLC-Racemization-Test with Fluorescencespectroscopic Detection of Peptide Diastereomers. Peptides 1992, C.H. Schneider, A. N. Eberle (Eds.), 1993 ESCOM Science Publishers B.V., 459-460

C. Griehl, D. Ströhl, H. Jeschkeit, E. Kleinpeter: Synthetische und NMR-spektroskopische Untersuchungen der Benzylaminaddition an N-Maleyl-aminosäurederivate. Monatshefte für Chemie 123, 647-654 (1992), DOI: 10.1007/BF00816859

C. Griehl, H. Jeschkeit, U. Schilken, A. Kolbe: Effects of Opposite Chirality of the Hydrogen Bonding Behaviour of Di- and Tripeptide Derivatives. J. Chem. Soc. Perkin Trans 2, 47-50 (1990)

C. Griehl, A. Kolbe: Untersuchungen zur Kinetik der 5(4H)-Oxazolonbildung von N-geschützten Dipeptiden. Z. Chem. 29, 450-451 (1989), DOI: 10.1002/zfch.19890291212

C. Griehl, H. Jeschkeit: Synthese von 5(4H)-Oxazolinonen mit EEDQ und IIDQ als Kondensationsmittel. Z. Chem. 28, 439-440 (1988)